home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 335.8 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000560| 38 0d 00 00 39 37 00 00 | 00 01 3d 18 05 00 39 0d |8...97..|..=...9.|
|00000570| 00 00 39 38 00 00 00 01 | 76 25 05 00 16 0c 00 00 |..98....|v%......|
|00000580| 39 39 00 00 00 01 8c 31 | 05 00 ba 0d 00 00 00 00 |99.....1|........|
|00000590| 00 00 00 00 46 3f 05 00 | 00 00 00 00 24 55 6e 69 |....F?..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 37 33 30 30 7d |que_ID{Y|RB07300}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 53 79 6d 70 74 6f 6d |..$Title|{Symptom|
|000005c0| 73 20 41 73 73 6f 63 69 | 61 74 65 64 20 57 69 74 |s Associ|ated Wit|
|000005d0| 68 20 56 61 67 69 6e 61 | 6c 20 43 6f 6c 6f 6e 69 |h Vagina|l Coloni|
|000005e0| 7a 61 74 69 6f 6e 20 57 | 69 74 68 20 59 65 61 73 |zation W|ith Yeas|
|000005f0| 74 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 4d 63 43 6f |t}..$Aut|hor{McCo|
|00000600| 72 6d 61 63 6b 2c 20 57 | 4d 0d 0a 53 74 61 72 6b |rmack, W|M..Stark|
|00000610| 6f 2c 20 4b 4d 0d 0a 5a | 69 6e 6e 65 72 2c 20 53 |o, KM..Z|inner, S|
|00000620| 48 7d 0d 0a 24 41 66 66 | 69 6c 69 61 74 69 6f 6e |H}..$Aff|iliation|
|00000630| 7b 48 61 72 76 61 72 64 | 20 55 6e 69 76 3b 20 53 |{Harvard| Univ; S|
|00000640| 74 61 74 65 20 55 6e 69 | 76 20 6f 66 20 4e 65 77 |tate Uni|v of New|
|00000650| 20 59 6f 72 6b 2c 20 42 | 72 6f 6f 6b 6c 79 6e 3b | York, B|rooklyn;|
|00000660| 20 42 72 6f 77 6e 20 55 | 6e 69 76 7d 0d 0a 24 53 | Brown U|niv}..$S|
|00000670| 75 62 6a 65 63 74 7b 59 | 65 61 73 74 20 76 61 67 |ubject{Y|east vag|
|00000680| 69 6e 61 6c 20 63 6f 6c | 6f 6e 69 7a 61 74 69 6f |inal col|onizatio|
|00000690| 6e 20 77 69 74 68 2c 20 | 73 79 6d 70 74 6f 6d 73 |n with, |symptoms|
|000006a0| 20 6f 66 3b 0d 0a 56 61 | 67 69 6e 61 20 63 6f 6c | of;..Va|gina col|
|000006b0| 6f 6e 69 7a 61 74 69 6f | 6e 20 77 69 74 68 20 79 |onizatio|n with y|
|000006c0| 65 61 73 74 2c 20 73 79 | 6d 70 74 6f 6d 73 20 6f |east, sy|mptoms o|
|000006d0| 66 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 41 6d 20 |f}..$Jou|rnal{Am |
|000006e0| 4a 20 4f 62 73 74 65 74 | 20 47 79 6e 65 63 6f 6c |J Obstet| Gynecol|
|000006f0| 7d 0d 0a 24 56 6f 6c 75 | 6d 65 7b 31 35 38 7d 0d |}..$Volu|me{158}.|
|00000700| 0a 24 50 61 67 65 7b 33 | 31 2d 33 33 7d 0d 0a 24 |.$Page{3|1-33}..$|
|00000710| 44 61 74 65 7b 4a 61 6e | 75 61 72 79 20 31 39 38 |Date{Jan|uary 198|
|00000720| 38 7d 0d 0a 24 59 42 56 | 6f 6c 7b 31 39 38 39 20 |8}..$YBV|ol{1989 |
|00000730| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 4f 62 73 |Year Boo|k of Obs|
|00000740| 74 65 74 72 69 63 73 20 | 61 6e 64 20 47 79 6e 65 |tetrics |and Gyne|
|00000750| 63 6f 6c 6f 67 79 7d 0d | 0a 24 43 68 61 70 74 65 |cology}.|.$Chapte|
|00000760| 72 7b 31 34 2d 31 32 7d | 0d 0a 24 59 42 45 64 69 |r{14-12}|..$YBEdi|
|00000770| 74 6f 72 7b 44 72 73 2e | 20 4d 69 73 68 65 6c 6c |tor{Drs.| Mishell|
|00000780| 2c 20 4b 69 72 73 63 68 | 62 61 75 6d 2c 20 61 6e |, Kirsch|baum, an|
|00000790| 64 20 4d 6f 72 72 6f 77 | 7d 0d 0a 24 54 61 62 6c |d Morrow|}..$Tabl|
|000007a0| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|000007b0| 72 7b 44 2e 52 2e 20 4d | 69 73 68 65 6c 6c 2c 20 |r{D.R. M|ishell, |
|000007c0| 4a 72 2e 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |Jr., M.D|.}....Co|
|000007d0| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
|000007e0| 20 42 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 | Book Me|dical Pu|
|000007f0| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 2c 20 |blishers|, Inc., |
|00000800| 31 39 38 39 0d 0a 0d 0a | 31 39 38 39 20 59 65 61 |1989....|1989 Yea|
|00000810| 72 20 42 6f 6f 6b 20 6f | 66 20 4f 62 73 74 65 74 |r Book o|f Obstet|
|00000820| 72 69 63 73 20 61 6e 64 | 20 47 79 6e 65 63 6f 6c |rics and| Gynecol|
|00000830| 6f 67 79 20 28 52 29 0d | 0a 0d 0a 47 79 6e 65 63 |ogy (R).|...Gynec|
|00000840| 6f 6c 6f 67 79 0d 0a 0d | 0a 43 68 61 70 74 65 72 |ology...|.Chapter|
|00000850| 20 31 34 2d 2d 49 6e 66 | 65 63 74 69 6f 6e 73 0d | 14--Inf|ections.|
|00000860| 0a 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |...-----|--------|
|00000870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008b0| 2d 2d 2d 0d 0a 53 79 6d | 70 74 6f 6d 73 20 41 73 |---..Sym|ptoms As|
|000008c0| 73 6f 63 69 61 74 65 64 | 20 57 69 74 68 20 56 61 |sociated| With Va|
|000008d0| 67 69 6e 61 6c 20 43 6f | 6c 6f 6e 69 7a 61 74 69 |ginal Co|lonizati|
|000008e0| 6f 6e 20 57 69 74 68 20 | 59 65 61 73 74 0d 0a 0d |on With |Yeast...|
|000008f0| 0a 4d 63 43 6f 72 6d 61 | 63 6b 20 57 4d 2c 20 53 |.McCorma|ck WM, S|
|00000900| 74 61 72 6b 6f 20 4b 4d | 2c 20 5a 69 6e 6e 65 72 |tarko KM|, Zinner|
|00000910| 20 53 48 0d 0a 28 48 61 | 72 76 61 72 64 20 55 6e | SH..(Ha|rvard Un|
|00000920| 69 76 3b 20 53 74 61 74 | 65 20 55 6e 69 76 20 6f |iv; Stat|e Univ o|
|00000930| 66 20 4e 65 77 20 59 6f | 72 6b 2c 20 42 72 6f 6f |f New Yo|rk, Broo|
|00000940| 6b 6c 79 6e 3b 20 42 72 | 6f 77 6e 20 55 6e 69 76 |klyn; Br|own Univ|
|00000950| 29 0d 0a 41 6d 20 4a 20 | 4f 62 73 74 65 74 20 47 |)..Am J |Obstet G|
|00000960| 79 6e 65 63 6f 6c 20 31 | 35 38 3a 33 31 2d 33 33 |ynecol 1|58:31-33|
|00000970| 2c 20 4a 61 6e 75 61 72 | 79 20 31 39 38 38 0d 0a |, Januar|y 1988..|
|00000980| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000990| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009d0| 0d 0a 0d 0a 41 62 73 74 | 72 61 63 74 0d 0a 0d 0a |....Abst|ract....|
|000009e0| 20 20 20 20 20 54 68 65 | 20 73 69 67 6e 69 66 69 | The| signifi|
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|00000a00| 76 61 67 69 6e 61 6c 20 | 63 6f 6c 6f 6e 69 7a 61 |vaginal |coloniza|
|00000a10| 74 69 6f 6e 20 72 65 6d | 61 69 6e 73 20 75 6e 63 |tion rem|ains unc|
|00000a20| 65 72 74 61 69 6e 2e 0d | 0a 56 75 6c 76 6f 76 61 |ertain..|.Vulvova|
|00000a30| 67 69 6e 61 6c 20 73 79 | 6d 70 74 6f 6d 73 20 77 |ginal sy|mptoms w|
|00000a40| 65 72 65 20 63 6f 72 72 | 65 6c 61 74 65 64 20 77 |ere corr|elated w|
|00000a50| 69 74 68 20 63 75 6c 74 | 75 72 65 73 20 66 6f 72 |ith cult|ures for|
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|00000a70| 6d 65 6e 20 73 65 65 6e | 0d 0a 69 6e 20 74 68 65 |men seen|..in the|
|00000a80| 20 68 65 61 6c 74 68 20 | 73 65 72 76 69 63 65 20 | health |service |
|00000a90| 6f 66 20 61 20 6c 61 72 | 67 65 20 75 72 62 61 6e |of a lar|ge urban|
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|00000ac0| 6e 61 6c 20 6f 72 0d 0a | 73 79 73 74 65 6d 69 63 |nal or..|systemic|
|00000ad0| 20 61 6e 74 69 62 69 6f | 74 69 63 73 20 69 6e 20 | antibio|tics in |
|00000ae0| 74 68 65 20 70 61 73 74 | 20 6d 6f 6e 74 68 2c 20 |the past| month, |
|00000af0| 6f 72 20 64 6f 75 63 68 | 65 73 20 6f 72 20 76 61 |or douch|es or va|
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|00000b10| 69 65 73 20 69 6e 0d 0a | 74 68 65 20 70 61 73 74 |ies in..|the past|
|00000b20| 20 77 65 65 6b 2e 20 20 | 42 6f 74 68 20 73 61 6c | week. |Both sal|
|00000b30| 69 6e 65 20 61 6e 64 20 | 70 6f 74 61 73 73 69 75 |ine and |potassiu|
|00000b40| 6d 20 68 79 64 72 6f 78 | 69 64 65 20 28 4b 4f 48 |m hydrox|ide (KOH|
|00000b50| 29 20 77 65 74 20 70 72 | 65 70 61 72 61 74 69 6f |) wet pr|eparatio|
|00000b60| 6e 73 20 77 65 72 65 0d | 0a 65 78 61 6d 69 6e 65 |ns were.|.examine|
|00000b70| 64 20 6d 69 63 72 6f 73 | 63 6f 70 69 63 61 6c 6c |d micros|copicall|
|00000b80| 79 2c 20 61 6e 64 20 73 | 70 65 63 69 6d 65 6e 73 |y, and s|pecimens|
|00000b90| 20 77 65 72 65 20 69 6e | 6f 63 75 6c 61 74 65 64 | were in|oculated|
|00000ba0| 20 69 6e 74 6f 20 54 72 | 69 63 68 6f 73 65 6c 20 | into Tr|ichosel |
|00000bb0| 62 72 6f 74 68 0d 0a 63 | 75 6c 74 75 72 65 73 2e |broth..c|ultures.|
|00000bc0| 0d 0a 20 20 20 20 20 54 | 68 65 20 73 74 75 64 79 |.. T|he study|
|00000bd0| 20 70 6f 70 75 6c 61 74 | 69 6f 6e 20 63 6f 6e 73 | populat|ion cons|
|00000be0| 69 73 74 65 64 20 63 68 | 69 65 66 6c 79 20 6f 66 |isted ch|iefly of|
|00000bf0| 20 79 6f 75 6e 67 20 77 | 68 69 74 65 20 66 65 6d | young w|hite fem|
|00000c00| 61 6c 65 73 20 69 6e 20 | 74 68 65 69 72 20 6c 61 |ales in |their la|
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|00000c20| 72 6c 79 20 32 30 73 2e | 20 20 4e 6f 6e 65 20 6f |rly 20s.| None o|
|00000c30| 66 20 74 68 65 20 77 6f | 6d 65 6e 20 68 61 64 20 |f the wo|men had |
|00000c40| 74 72 69 63 68 6f 6d 6f | 6e 69 61 73 69 73 2e 20 |trichomo|niasis. |
|00000c50| 20 59 65 61 73 74 73 20 | 77 65 72 65 20 66 6f 75 | Yeasts |were fou|
|00000c60| 6e 64 0d 0a 69 6e 20 4b | 4f 48 20 77 65 74 20 70 |nd..in K|OH wet p|
|00000c70| 72 65 70 61 72 61 74 69 | 6f 6e 73 20 69 6e 20 34 |reparati|ons in 4|
|00000c80| 20 6f 66 20 35 34 20 77 | 6f 6d 65 6e 20 73 65 65 | of 54 w|omen see|
|00000c90| 6e 20 62 79 20 61 20 70 | 68 79 73 69 63 69 61 6e |n by a p|hysician|
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|00000cb0| 0d 0a 65 78 61 6d 69 6e | 61 74 69 6f 6e 20 66 6f |..examin|ation fo|
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|00000cd0| 20 77 65 72 65 20 69 73 | 6f 6c 61 74 65 64 20 66 | were is|olated f|
|00000ce0| 72 6f 6d 20 31 38 20 6f | 66 20 74 68 65 6d 2e 20 |rom 18 o|f them. |
|00000cf0| 20 4f 66 20 39 30 20 6f | 74 68 65 72 20 77 6f 6d | Of 90 o|ther wom|
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|00000d20| 20 65 78 61 6d 69 6e 61 | 74 69 6f 6e 20 62 79 20 | examina|tion by |
|00000d30| 61 20 6e 75 72 73 65 20 | 70 72 61 63 74 69 74 69 |a nurse |practiti|
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|00001de0| 6e 61 74 69 6f 6e 20 6f | 66 20 74 68 65 0d 0a 63 |nation o|f the..c|
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|00001e50| 65 20 77 69 74 68 20 74 | 68 65 20 32 20 6d 65 64 |e with t|he 2 med|
|00001e60| 69 61 20 75 73 65 64 20 | 69 6e 20 74 68 69 73 20 |ia used |in this |
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|00002020| 20 20 43 6f 6c 70 6f 73 | 63 6f 70 79 2c 20 43 79 | Colpos|copy, Cy|
|00002030| 74 6f 6c 6f 67 79 2c 20 | 61 6e 64 20 48 69 73 74 |tology, |and Hist|
|00002040| 6f 6c 6f 67 79 7d 0d 0a | 24 41 75 74 68 6f 72 7b |ology}..|$Author{|
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|00002070| 6c 69 61 74 69 6f 6e 7b | 4d 65 64 20 43 6f 6c 6c |liation{|Med Coll|
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|000020a0| 6a 65 63 74 7b 50 65 6e | 69 73 20 70 61 70 69 6c |ject{Pen|is papil|
|000020b0| 6c 6f 6d 61 76 69 72 75 | 73 2d 61 73 73 6f 63 69 |lomaviru|s-associ|
|000020c0| 61 74 65 64 20 6c 65 73 | 69 6f 6e 73 3b 0d 0a 50 |ated les|ions;..P|
|000020d0| 61 70 69 6c 6c 6f 6d 61 | 76 69 72 75 73 2c 20 70 |apilloma|virus, p|
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|00002110| 6f 6d 61 76 69 72 75 73 | 2d 61 73 73 6f 63 69 61 |omavirus|-associa|
|00002120| 74 65 64 20 6c 65 73 69 | 6f 6e 73 3b 0d 0a 43 6f |ted lesi|ons;..Co|
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|00002140| 73 20 69 6e 20 70 61 70 | 69 6c 6c 6f 6d 61 76 69 |s in pap|illomavi|
|00002150| 72 75 73 2d 61 73 73 6f | 63 69 61 74 65 64 20 6c |rus-asso|ciated l|
|00002160| 65 73 69 6f 6e 73 7d 0d | 0a 24 4a 6f 75 72 6e 61 |esions}.|.$Journa|
|00002170| 6c 7b 4f 62 73 74 65 74 | 20 47 79 6e 65 63 6f 6c |l{Obstet| Gynecol|
|00002180| 7d 0d 0a 24 56 6f 6c 75 | 6d 65 7b 37 30 7d 0d 0a |}..$Volu|me{70}..|
|00002190| 24 50 61 67 65 7b 32 39 | 39 2d 33 30 34 7d 0d 0a |$Page{29|9-304}..|
|000021a0| 24 44 61 74 65 7b 53 65 | 70 74 65 6d 62 65 72 20 |$Date{Se|ptember |
|000021b0| 31 39 38 37 7d 0d 0a 24 | 59 42 56 6f 6c 7b 31 39 |1987}..$|YBVol{19|
|000021c0| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
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|000021e0| 79 6e 65 63 6f 6c 6f 67 | 79 7d 0d 0a 24 43 68 61 |ynecolog|y}..$Cha|
|000021f0| 70 74 65 72 7b 31 34 2d | 31 34 7d 0d 0a 24 59 42 |pter{14-|14}..$YB|
|00002200| 45 64 69 74 6f 72 7b 44 | 72 73 2e 20 4d 69 73 68 |Editor{D|rs. Mish|
|00002210| 65 6c 6c 2c 20 4b 69 72 | 73 63 68 62 61 75 6d 2c |ell, Kir|schbaum,|
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|00002260| 4a 72 2e 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |Jr., M.D|.}....Co|
|00002270| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
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|00002290| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 2c 20 |blishers|, Inc., |
|000022a0| 31 39 38 39 0d 0a 0d 0a | 31 39 38 39 20 59 65 61 |1989....|1989 Yea|
|000022b0| 72 20 42 6f 6f 6b 20 6f | 66 20 4f 62 73 74 65 74 |r Book o|f Obstet|
|000022c0| 72 69 63 73 20 61 6e 64 | 20 47 79 6e 65 63 6f 6c |rics and| Gynecol|
|000022d0| 6f 67 79 20 28 52 29 0d | 0a 0d 0a 47 79 6e 65 63 |ogy (R).|...Gynec|
|000022e0| 6f 6c 6f 67 79 0d 0a 0d | 0a 43 68 61 70 74 65 72 |ology...|.Chapter|
|000022f0| 20 31 34 2d 2d 49 6e 66 | 65 63 74 69 6f 6e 73 0d | 14--Inf|ections.|
|00002300| 0a 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |...-----|--------|
|00002310| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002320| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002330| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002340| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002350| 2d 2d 2d 0d 0a 48 75 6d | 61 6e 20 50 61 70 69 6c |---..Hum|an Papil|
|00002360| 6c 6f 6d 61 76 69 72 75 | 73 2d 41 73 73 6f 63 69 |lomaviru|s-Associ|
|00002370| 61 74 65 64 20 4c 65 73 | 69 6f 6e 73 20 6f 66 20 |ated Les|ions of |
|00002380| 74 68 65 20 50 65 6e 69 | 73 3a 20 20 43 6f 6c 70 |the Peni|s: Colp|
|00002390| 6f 73 63 6f 70 79 2c 20 | 43 79 74 6f 6c 6f 67 79 |oscopy, |Cytology|
|000023a0| 2c 20 61 6e 64 0d 0a 48 | 69 73 74 6f 6c 6f 67 79 |, and..H|istology|
|000023b0| 0d 0a 0d 0a 4b 72 65 62 | 73 20 48 2d 42 2c 20 53 |....Kreb|s H-B, S|
|000023c0| 63 68 6e 65 69 64 65 72 | 20 56 0d 0a 28 4d 65 64 |chneider| V..(Med|
|000023d0| 20 43 6f 6c 6c 65 67 65 | 20 6f 66 20 56 69 72 67 | College| of Virg|
|000023e0| 69 6e 69 61 2c 20 52 69 | 63 68 6d 6f 6e 64 29 0d |inia, Ri|chmond).|
|000023f0| 0a 4f 62 73 74 65 74 20 | 47 79 6e 65 63 6f 6c 20 |.Obstet |Gynecol |
|00002400| 37 30 3a 32 39 39 2d 33 | 30 34 2c 20 53 65 70 74 |70:299-3|04, Sept|
|00002410| 65 6d 62 65 72 20 31 39 | 38 37 0d 0a 2d 2d 2d 2d |ember 19|87..----|
|00002420| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002430| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002440| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002450| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002460| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00002470| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00002480| 20 54 68 65 20 64 69 61 | 67 6e 6f 73 69 73 20 61 | The dia|gnosis a|
|00002490| 6e 64 20 74 68 65 72 61 | 70 79 20 6f 66 20 68 75 |nd thera|py of hu|
|000024a0| 6d 61 6e 20 70 61 70 69 | 6c 6c 6f 6d 61 76 69 72 |man papi|llomavir|
|000024b0| 75 73 20 69 6e 66 65 63 | 74 69 6f 6e 20 69 6e 20 |us infec|tion in |
|000024c0| 6d 65 6e 20 69 73 0d 0a | 70 6f 74 65 6e 74 69 61 |men is..|potentia|
|000024d0| 6c 6c 79 20 62 65 6e 65 | 66 69 63 69 61 6c 2c 20 |lly bene|ficial, |
|000024e0| 62 65 63 61 75 73 65 20 | 69 74 20 6d 61 79 20 64 |because |it may d|
|000024f0| 65 63 72 65 61 73 65 20 | 74 68 65 20 72 65 73 65 |ecrease |the rese|
|00002500| 72 76 6f 69 72 20 6f 66 | 20 74 68 65 20 76 69 72 |rvoir of| the vir|
|00002510| 75 73 20 66 72 6f 6d 0d | 0a 77 68 69 63 68 20 67 |us from.|.which g|
|00002520| 65 6e 69 74 61 6c 20 63 | 6f 6e 64 79 6c 6f 6d 61 |enital c|ondyloma|
|00002530| 74 61 20 6f 72 20 73 71 | 75 61 6d 6f 75 73 20 6d |ta or sq|uamous m|
|00002540| 65 74 61 70 6c 61 73 69 | 61 20 6d 61 79 20 61 72 |etaplasi|a may ar|
|00002550| 69 73 65 20 69 6e 20 77 | 6f 6d 65 6e 2e 20 20 54 |ise in w|omen. T|
|00002560| 68 65 0d 0a 65 66 66 65 | 63 74 69 76 65 6e 65 73 |he..effe|ctivenes|
|00002570| 73 20 6f 66 20 63 6f 6c | 70 6f 73 63 6f 70 79 2c |s of col|poscopy,|
|00002580| 20 63 79 74 6f 6c 6f 67 | 79 2c 20 61 6e 64 20 68 | cytolog|y, and h|
|00002590| 69 73 74 6f 6c 6f 67 79 | 20 69 6e 20 74 68 65 20 |istology| in the |
|000025a0| 64 69 61 67 6e 6f 73 69 | 73 20 6f 66 20 70 65 6e |diagnosi|s of pen|
|000025b0| 69 6c 65 0d 0a 63 6f 6e | 64 79 6c 6f 6d 61 74 61 |ile..con|dylomata|
|000025c0| 20 77 61 73 20 69 6e 76 | 65 73 74 69 67 61 74 65 | was inv|estigate|
|000025d0| 64 20 69 6e 20 31 32 37 | 20 6d 61 6c 65 20 73 65 |d in 127| male se|
|000025e0| 78 75 61 6c 20 70 61 72 | 74 6e 65 72 73 20 6f 66 |xual par|tners of|
|000025f0| 20 31 32 37 20 77 6f 6d | 65 6e 20 77 69 74 68 0d | 127 wom|en with.|
|00002600| 0a 63 65 72 76 69 63 61 | 6c 20 69 6e 74 72 61 65 |.cervica|l intrae|
|00002610| 70 69 74 68 65 6c 69 61 | 6c 20 6e 65 6f 70 6c 61 |pithelia|l neopla|
|00002620| 73 69 61 2e 0d 0a 20 20 | 20 20 20 45 69 67 68 74 |sia... | Eight|
|00002630| 79 2d 74 68 72 65 65 20 | 6d 65 6e 20 28 36 35 25 |y-three |men (65%|
|00002640| 29 20 68 61 64 20 68 75 | 6d 61 6e 20 70 61 70 69 |) had hu|man papi|
|00002650| 6c 6c 6f 6d 61 76 69 72 | 75 73 2d 61 73 73 6f 63 |llomavir|us-assoc|
|00002660| 69 61 74 65 64 20 6c 65 | 73 69 6f 6e 73 0d 0a 63 |iated le|sions..c|
|00002670| 6f 6e 73 69 73 74 69 6e | 67 20 6f 66 20 63 6f 6e |onsistin|g of con|
|00002680| 64 79 6c 6f 6d 61 74 61 | 20 69 6e 20 38 30 20 61 |dylomata| in 80 a|
|00002690| 6e 64 20 70 65 6e 69 6c | 65 20 64 79 73 70 6c 61 |nd penil|e dyspla|
|000026a0| 73 69 61 20 69 6e 20 33 | 2e 20 20 4f 6e 6c 79 20 |sia in 3|. Only |
|000026b0| 32 34 25 20 77 65 72 65 | 20 61 77 61 72 65 0d 0a |24% were| aware..|
|000026c0| 6f 66 20 61 6e 79 20 67 | 65 6e 69 74 61 6c 20 6c |of any g|enital l|
|000026d0| 65 73 69 6f 6e 73 2c 20 | 61 6e 64 20 6f 6e 6c 79 |esions, |and only|
|000026e0| 20 36 25 20 68 61 64 20 | 73 79 6d 70 74 6f 6d 73 | 6% had |symptoms|
|000026f0| 2e 20 20 54 68 65 20 6c | 65 73 69 6f 6e 73 20 6e |. The l|esions n|
|00002700| 75 6d 62 65 72 65 64 20 | 66 72 6f 6d 20 31 0d 0a |umbered |from 1..|
|00002710| 74 6f 20 35 30 20 28 6d | 65 64 69 61 6e 2c 20 33 |to 50 (m|edian, 3|
|00002720| 29 20 61 6e 64 20 77 65 | 72 65 20 73 6d 61 6c 6c |) and we|re small|
|00002730| 20 28 6d 65 64 69 61 6e | 2c 20 33 20 6d 6d 29 2e | (median|, 3 mm).|
|00002740| 20 20 54 68 65 20 63 6f | 6c 70 6f 73 63 6f 70 65 | The co|lposcope|
|00002750| 20 61 69 64 65 64 20 64 | 69 61 67 6e 6f 73 69 73 | aided d|iagnosis|
|00002760| 0d 0a 6f 72 20 77 61 73 | 20 6e 65 63 65 73 73 61 |..or was| necessa|
|00002770| 72 79 20 66 6f 72 20 64 | 69 61 67 6e 6f 73 69 73 |ry for d|iagnosis|
|00002780| 20 69 6e 20 35 39 25 20 | 6f 66 20 74 68 65 20 6c | in 59% |of the l|
|00002790| 65 73 69 6f 6e 73 2e 20 | 20 41 70 70 6c 69 63 61 |esions. | Applica|
|000027a0| 74 69 6f 6e 20 6f 66 20 | 33 25 20 6f 72 20 35 25 |tion of |3% or 5%|
|000027b0| 0d 0a 61 63 65 74 69 63 | 20 61 63 69 64 20 72 65 |..acetic| acid re|
|000027c0| 76 65 61 6c 65 64 20 77 | 68 69 74 65 20 6f 72 20 |vealed w|hite or |
|000027d0| 67 72 61 79 20 65 70 69 | 74 68 65 6c 69 61 6c 20 |gray epi|thelial |
|000027e0| 63 68 61 6e 67 65 73 20 | 69 6e 20 32 32 25 20 6f |changes |in 22% o|
|000027f0| 66 20 70 61 74 69 65 6e | 74 73 2c 20 77 68 69 63 |f patien|ts, whic|
|00002800| 68 0d 0a 77 6f 75 6c 64 | 20 68 61 76 65 20 62 65 |h..would| have be|
|00002810| 65 6e 20 6d 69 73 73 65 | 64 20 77 69 74 68 6f 75 |en misse|d withou|
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|00003fe0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|000040a0| 38 2d 37 31 2c 20 4a 75 | 6c 79 20 31 39 38 37 0d |8-71, Ju|ly 1987.|
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|000040d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000040e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000040f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004c10| 67 68 74 20 28 63 29 20 | 59 65 61 72 20 42 6f 6f |ght (c) |Year Boo|
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|00004d20| 6f 6d 61 74 61 20 41 63 | 75 6d 69 6e 61 74 61 0d |omata Ac|uminata.|
|00004d30| 0a 0d 0a 46 72 69 65 64 | 6d 61 6e 2d 4b 69 65 6e |...Fried|man-Kien|
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|00004e50| 20 52 75 74 67 65 72 73 | 20 55 6e 69 76 29 0d 0a | Rutgers| Univ)..|
|00004e60| 4a 41 4d 41 20 32 35 39 | 3a 35 33 33 2d 35 33 38 |JAMA 259|:533-538|
|00004e70| 2c 20 4a 61 6e 20 32 32 | 2f 32 39 2c 20 31 39 38 |, Jan 22|/29, 198|
|00004e80| 38 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |8..-----|--------|
|00004e90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005ac0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005b40| 65 73 0d 0a 0d 0a 4d 69 | 6e 64 65 6c 20 41 2c 20 |es....Mi|ndel A, |
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|00005b70| 65 72 69 73 20 4d 2c 20 | 57 69 6c 6c 69 61 6d 73 |eris M, |Williams|
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|00005c50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005da0| 0d 0a 74 72 65 61 74 65 | 64 20 66 6f 72 20 31 20 |..treate|d for 1 |
|00005db0| 79 65 61 72 20 77 69 74 | 68 20 72 65 64 75 63 69 |year wit|h reduci|
|00005dc0| 6e 67 20 64 6f 73 65 73 | 20 6f 66 20 6f 72 61 6c |ng doses| of oral|
|00005dd0| 20 61 63 79 63 6c 6f 76 | 69 72 2e 0d 0a 20 20 20 | acyclov|ir... |
|00005de0| 20 20 41 6c 6c 20 70 61 | 74 69 65 6e 74 73 20 69 | All pa|tients i|
|00005df0| 6e 69 74 69 61 6c 6c 79 | 20 72 65 63 65 69 76 65 |nitially| receive|
|00005e00| 64 20 61 63 79 63 6c 6f | 76 69 72 2c 20 32 30 30 |d acyclo|vir, 200|
|00005e10| 20 6d 67 20 35 20 74 69 | 6d 65 73 20 64 61 69 6c | mg 5 ti|mes dail|
|00005e20| 79 20 66 6f 72 20 35 20 | 64 61 79 73 2e 0d 0a 54 |y for 5 |days...T|
|00005e30| 68 65 20 70 61 74 69 65 | 6e 74 73 20 77 65 72 65 |he patie|nts were|
|00005e40| 20 74 68 65 6e 20 72 61 | 6e 64 6f 6d 69 7a 65 64 | then ra|ndomized|
|00005e50| 20 74 6f 20 32 20 74 72 | 65 61 74 6d 65 6e 74 20 | to 2 tr|eatment |
|00005e60| 73 63 68 65 64 75 6c 65 | 73 3a 20 20 73 63 68 65 |schedule|s: sche|
|00005e70| 64 75 6c 65 20 41 0d 0a | 63 6f 6e 73 69 73 74 65 |dule A..|consiste|
|00005e80| 64 20 6f 66 20 61 63 79 | 63 6c 6f 76 69 72 2c 20 |d of acy|clovir, |
|00005e90| 32 30 30 20 6d 67 20 34 | 20 74 69 6d 65 73 20 64 |200 mg 4| times d|
|00005ea0| 61 69 6c 79 20 66 6f 72 | 20 31 32 20 77 65 65 6b |aily for| 12 week|
|00005eb0| 73 2c 20 72 65 64 75 63 | 69 6e 67 20 74 68 65 0d |s, reduc|ing the.|
|00005ec0| 0a 66 72 65 71 75 65 6e | 63 79 20 61 74 20 31 32 |.frequen|cy at 12|
|00005ed0| 2d 77 65 65 6b 20 69 6e | 74 65 72 76 61 6c 73 20 |-week in|tervals |
|00005ee0| 75 6e 74 69 6c 20 32 30 | 30 20 6d 67 20 6f 6e 63 |until 20|0 mg onc|
|00005ef0| 65 20 64 61 69 6c 79 20 | 77 61 73 20 61 63 68 69 |e daily |was achi|
|00005f00| 65 76 65 64 3b 20 61 6e | 64 0d 0a 73 63 68 65 64 |eved; an|d..sched|
|00005f10| 75 6c 65 20 42 2c 20 34 | 30 30 20 6d 67 20 74 77 |ule B, 4|00 mg tw|
|00005f20| 69 63 65 20 64 61 69 6c | 79 2c 20 38 30 30 20 6d |ice dail|y, 800 m|
|00005f30| 67 20 6f 6e 63 65 20 64 | 61 69 6c 79 2c 20 34 30 |g once d|aily, 40|
|00005f40| 30 20 6d 67 20 6f 6e 63 | 65 20 61 20 64 61 79 2c |0 mg onc|e a day,|
|00005f50| 20 61 6e 64 20 32 30 30 | 20 6d 67 0d 0a 6f 6e 63 | and 200| mg..onc|
|00005f60| 65 20 61 20 64 61 79 20 | 66 6f 72 20 74 68 65 20 |e a day |for the |
|00005f70| 66 6f 75 72 20 31 32 2d | 77 65 65 6b 20 70 65 72 |four 12-|week per|
|00005f80| 69 6f 64 73 2e 0d 0a 20 | 20 20 20 20 54 68 65 20 |iods... | The |
|00005f90| 74 69 6d 65 20 74 6f 20 | 66 69 72 73 74 20 72 65 |time to |first re|
|00005fa0| 63 75 72 72 65 6e 63 65 | 20 77 61 73 20 72 65 6c |currence| was rel|
|00005fb0| 61 74 65 64 20 62 6f 74 | 68 20 74 6f 20 74 68 65 |ated bot|h to the|
|00005fc0| 20 74 6f 74 61 6c 20 64 | 61 69 6c 79 20 64 6f 73 | total d|aily dos|
|00005fd0| 65 20 6f 66 0d 0a 61 63 | 79 63 6c 6f 76 69 72 20 |e of..ac|yclovir |
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|00005ff0| 79 20 6f 66 20 74 61 62 | 6c 65 74 20 74 61 6b 69 |y of tab|let taki|
|00006000| 6e 67 2e 20 20 54 68 65 | 20 74 69 6d 65 20 74 6f |ng. The| time to|
|00006010| 20 66 69 72 73 74 20 72 | 65 63 75 72 72 65 6e 63 | first r|ecurrenc|
|00006020| 65 20 69 6e 0d 0a 70 61 | 74 69 65 6e 74 73 20 77 |e in..pa|tients w|
|00006030| 68 6f 20 63 6f 6d 6d 65 | 6e 63 65 64 20 74 68 65 |ho comme|nced the|
|00006040| 72 61 70 79 20 77 69 74 | 68 20 34 30 30 20 6d 67 |rapy wit|h 400 mg|
|00006050| 20 74 77 69 63 65 20 61 | 20 64 61 79 20 77 61 73 | twice a| day was|
|00006060| 20 73 69 67 6e 69 66 69 | 63 61 6e 74 6c 79 20 73 | signifi|cantly s|
|00006070| 68 6f 72 74 65 72 0d 0a | 74 68 61 6e 20 74 68 61 |horter..|than tha|
|00006080| 74 20 69 6e 20 70 61 74 | 69 65 6e 74 73 20 67 69 |t in pat|ients gi|
|00006090| 76 65 6e 20 32 30 30 20 | 6d 67 20 34 20 74 69 6d |ven 200 |mg 4 tim|
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|000060b0| 65 20 74 6f 74 61 6c 20 | 64 61 69 6c 79 20 64 6f |e total |daily do|
|000060c0| 73 65 20 61 6e 64 0d 0a | 66 72 65 71 75 65 6e 63 |se and..|frequenc|
|000060d0| 79 20 6f 66 20 74 68 65 | 72 61 70 79 20 77 61 73 |y of the|rapy was|
|000060e0| 20 6c 6f 77 65 72 65 64 | 2c 20 73 6f 20 74 68 65 | lowered|, so the|
|000060f0| 20 74 69 6d 65 20 74 6f | 20 66 69 72 73 74 20 72 | time to| first r|
|00006100| 65 63 75 72 72 65 6e 63 | 65 20 77 61 73 20 73 68 |ecurrenc|e was sh|
|00006110| 6f 72 74 65 6e 65 64 2e | 0d 0a 41 74 20 74 68 65 |ortened.|..At the|
|00006120| 20 65 6e 64 20 6f 66 20 | 36 30 20 64 61 79 73 2c | end of |60 days,|
|00006130| 20 35 36 25 20 6f 66 20 | 70 61 74 69 65 6e 74 73 | 56% of |patients|
|00006140| 20 74 61 6b 69 6e 67 20 | 32 30 30 20 6d 67 20 6f | taking |200 mg o|
|00006150| 6e 63 65 20 61 20 64 61 | 79 20 68 61 64 20 72 65 |nce a da|y had re|
|00006160| 63 75 72 72 65 6e 63 65 | 73 2e 0d 0a 54 68 65 72 |currence|s...Ther|
|00006170| 65 20 77 61 73 20 61 20 | 73 69 67 6e 69 66 69 63 |e was a |signific|
|00006180| 61 6e 74 20 6d 61 72 6b | 65 64 20 72 65 64 75 63 |ant mark|ed reduc|
|00006190| 74 69 6f 6e 20 69 6e 20 | 74 68 65 20 66 72 65 71 |tion in |the freq|
|000061a0| 75 65 6e 63 79 20 6f 66 | 20 72 65 63 75 72 72 65 |uency of| recurre|
|000061b0| 6e 63 65 20 64 75 72 69 | 6e 67 0d 0a 74 68 65 72 |nce duri|ng..ther|
|000061c0| 61 70 79 2c 20 66 72 6f | 6d 20 61 20 6d 65 61 6e |apy, fro|m a mean|
|000061d0| 20 31 2e 31 20 70 65 72 | 20 32 38 20 64 61 79 73 | 1.1 per| 28 days|
|000061e0| 20 62 65 66 6f 72 65 20 | 74 6f 20 30 2e 31 31 20 | before |to 0.11 |
|000061f0| 64 75 72 69 6e 67 20 74 | 72 65 61 74 6d 65 6e 74 |during t|reatment|
|00006200| 2e 20 20 54 68 65 0d 0a | 66 72 65 71 75 65 6e 63 |. The..|frequenc|
|00006210| 79 20 6f 66 20 72 65 63 | 75 72 72 65 6e 63 65 73 |y of rec|urrences|
|00006220| 20 77 61 73 20 73 69 67 | 6e 69 66 69 63 61 6e 74 | was sig|nificant|
|00006230| 6c 79 20 6c 6f 73 73 20 | 61 66 74 65 72 20 64 69 |ly loss |after di|
|00006240| 73 63 6f 6e 74 69 6e 75 | 69 6e 67 20 74 72 65 61 |scontinu|ing trea|
|00006250| 74 6d 65 6e 74 0d 0a 74 | 68 61 6e 20 69 6e 20 74 |tment..t|han in t|
|00006260| 68 65 20 70 72 65 74 72 | 65 61 74 6d 65 6e 74 20 |he pretr|eatment |
|00006270| 70 65 72 69 6f 64 2e 20 | 20 54 68 65 72 65 20 77 |period. | There w|
|00006280| 65 72 65 20 6e 6f 20 69 | 6d 70 6f 72 74 61 6e 74 |ere no i|mportant|
|00006290| 20 73 69 64 65 20 65 66 | 66 65 63 74 73 20 6e 6f | side ef|fects no|
|000062a0| 74 65 64 2e 0d 0a 20 20 | 20 20 20 4c 6f 6e 67 2d |ted... | Long-|
|000062b0| 74 65 72 6d 20 73 75 70 | 70 72 65 73 73 69 6f 6e |term sup|pression|
|000062c0| 20 77 69 74 68 20 61 63 | 79 63 6c 6f 76 69 72 20 | with ac|yclovir |
|000062d0| 69 73 20 73 61 66 65 20 | 61 6e 64 20 65 66 66 65 |is safe |and effe|
|000062e0| 63 74 69 76 65 20 66 6f | 72 20 70 61 74 69 65 6e |ctive fo|r patien|
|000062f0| 74 73 0d 0a 77 69 74 68 | 20 72 65 63 75 72 72 65 |ts..with| recurre|
|00006300| 6e 74 20 67 65 6e 69 74 | 61 6c 20 68 65 72 70 65 |nt genit|al herpe|
|00006310| 73 2e 20 20 41 6c 6c 20 | 70 61 74 69 65 6e 74 73 |s. All |patients|
|00006320| 20 73 68 6f 75 6c 64 20 | 73 74 61 72 74 20 77 69 | should |start wi|
|00006330| 74 68 20 61 20 64 6f 73 | 65 20 6f 66 20 32 30 30 |th a dos|e of 200|
|00006340| 20 6d 67 0d 0a 34 20 74 | 69 6d 65 73 20 61 20 64 | mg..4 t|imes a d|
|00006350| 61 79 20 61 6e 64 20 64 | 65 63 72 65 61 73 65 20 |ay and d|ecrease |
|00006360| 74 68 69 73 20 74 6f 20 | 32 30 30 20 6d 67 20 33 |this to |200 mg 3|
|00006370| 20 74 69 6d 65 73 20 61 | 20 64 61 79 20 61 66 74 | times a| day aft|
|00006380| 65 72 20 32 2d 33 20 6d | 6f 6e 74 68 73 20 69 66 |er 2-3 m|onths if|
|00006390| 0d 0a 74 68 65 72 65 20 | 68 61 73 20 62 65 65 6e |..there |has been|
|000063a0| 20 6e 6f 20 72 65 63 75 | 72 72 65 6e 63 65 2e 20 | no recu|rrence. |
|000063b0| 20 46 75 72 74 68 65 72 | 20 72 65 64 75 63 74 69 | Further| reducti|
|000063c0| 6f 6e 73 20 74 6f 20 32 | 30 30 20 6d 67 20 74 77 |ons to 2|00 mg tw|
|000063d0| 69 63 65 20 61 20 64 61 | 79 2c 20 61 6e 64 0d 0a |ice a da|y, and..|
|000063e0| 65 76 65 6e 74 75 61 6c | 6c 79 20 74 6f 20 6f 6e |eventual|ly to on|
|000063f0| 63 65 20 61 20 64 61 79 | 2c 20 6d 61 79 20 62 65 |ce a day|, may be|
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